01-Nov-2018 2:40 PM

Research released this year has identified a hormone released by bone cells that targets the part of our brains that makes us hungry. A recent study on mice conducted by Columbia University Medical Center has found that a new function of bone has been added to the list: appetite suppression.

Researchers found that bone cells secrete a hormone called lipocalin 2 which, because of its chemical structure, had previously been identified as a protein that was secreted by fat cells. This hormone is released after eating and reaches peak levels approximately one hour after the meal has been consumed. The latest study shows that 90 percent of lipocalin 2 is actually produced by osteoblasts – bone cells that are responsible for building new bone.

The study involved breeding two types of mice: one whose fat cells could not produce lipocalin 2, and one type whose bone cells couldn’t produce lipocalin 2. They compared the two groups to normal “wild type” mice. The mice with the defective lipocalin 2 genes in bones were found to have 20 percent more body fat and ate 16 percent more food than mice whose fat cells couldn’t produce lipocalin 2. This group also had poor blood sugar control and insulin resistance. These results suggested that the bone-derived lipocalin 2 alone was responsible for the changes in appetite and metabolism.

When the mice with the broken gene were given lipocalin 2, their eating returned to normal. Injections of the hormone into healthy mice reduced the amount they ate and helped to regulate glucose and insulin levels. In all types of mice, lipocalin 2 suppressed appetite, improved overall metabolism, and reduced body weight. This was attributed to the lipocalin 2 affecting the parts of the brain that control hunger.

Luckily, lipocalin 2 is released by human bone cells. Researchers tested levels of the hormone in a group of patients with type 2 diabetes who had elevated insulin and glucose levels and measured them against a healthy group. The results showed that those with higher levels of lipocalin 2 after eating had lower body weights and levels of blood sugar. It seems that the lipocalin 2 suppresses the appetite similar to how a slimming pill might – but best of all, it occurs naturally in our bodies.

This is great news for people who do exercises to build bone density, such as LES MILLS BODYPUMP. High impact training places a stress on bone, which also results in an increase in bone density.

We’ve long known that high impact and resistance training is great for improving cardiovascular fitness and promoting the growth of lean muscle tissue. Now we potentially have another benefit to add to the list: helping us to regulate our metabolism and lose weight.

For more information contact Emily Flint at Les Mills Asia Pacific e: p: 6215 8105


Topic: General News

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